全文获取类型
收费全文 | 15536篇 |
免费 | 1316篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 223篇 |
儿科学 | 692篇 |
妇产科学 | 398篇 |
基础医学 | 2499篇 |
口腔科学 | 234篇 |
临床医学 | 1869篇 |
内科学 | 2584篇 |
皮肤病学 | 241篇 |
神经病学 | 1209篇 |
特种医学 | 454篇 |
外科学 | 2557篇 |
综合类 | 97篇 |
一般理论 | 6篇 |
预防医学 | 1796篇 |
眼科学 | 282篇 |
药学 | 797篇 |
中国医学 | 11篇 |
肿瘤学 | 917篇 |
出版年
2023年 | 308篇 |
2022年 | 416篇 |
2021年 | 469篇 |
2020年 | 511篇 |
2019年 | 368篇 |
2018年 | 468篇 |
2017年 | 463篇 |
2016年 | 498篇 |
2015年 | 488篇 |
2014年 | 766篇 |
2013年 | 849篇 |
2012年 | 624篇 |
2011年 | 616篇 |
2010年 | 590篇 |
2009年 | 536篇 |
2008年 | 548篇 |
2007年 | 609篇 |
2006年 | 595篇 |
2005年 | 536篇 |
2004年 | 488篇 |
2003年 | 504篇 |
2002年 | 559篇 |
2001年 | 510篇 |
2000年 | 453篇 |
1999年 | 456篇 |
1998年 | 246篇 |
1997年 | 200篇 |
1996年 | 251篇 |
1995年 | 205篇 |
1994年 | 212篇 |
1993年 | 187篇 |
1992年 | 292篇 |
1991年 | 316篇 |
1990年 | 292篇 |
1989年 | 265篇 |
1988年 | 249篇 |
1987年 | 127篇 |
1986年 | 59篇 |
1985年 | 87篇 |
1984年 | 68篇 |
1983年 | 59篇 |
1982年 | 73篇 |
1981年 | 57篇 |
1980年 | 48篇 |
1979年 | 65篇 |
1978年 | 64篇 |
1977年 | 33篇 |
1976年 | 33篇 |
1975年 | 27篇 |
1974年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
1.
2.
3.
4.
Liam Masterson James Howard Jazmina Gonzalez-Cruz Christopher Jackson Catherine Barnett Lewis Overton Howard Liu Rahul Ladwa Fiona Simpson Margie McGrath Ben Wallwork Terry Jones Christian Ottensmeier Melvin L.K. Chua Chris Perry Rajiv Khanna Benedict Panizza Sandro Porceddu Matt Lechner 《International journal of cancer. Journal international du cancer》2020,146(8):2305-2314
Now is an exciting era of development in immunotherapy checkpoint inhibitors and their effect on the treatment of NPC. While the general prognosis of R/M disease is poor, immunotherapy offers some promise in a malignancy associated with EBV and characterized by a peritumoural immune infiltrate. Our study aims to review past and on-going clinical trials of monoclonal antibody therapies against the checkpoint inhibitors (e.g. PD1 and CTLA-4), in R/M NPC. All randomized and nonrandomized controlled trials involving immune checkpoint inhibitor interventions for treatment of NPC were included in the study. We utilized a validated “risk of bias” tool to assess study quality. Four separate Phase I–II trials report the potential of PD1 inhibitor treatment for patients with NPC. Within the observed groups, camrelizumab combined with chemotherapy achieved an objective response in 91% of patients as first-line treatment for metastatic NPC (PFS 68% at 1-year) but this was associated with a high rate of grade >3 adverse events (87%; CTCAE version 4.03). The remaining three studies focused on recurrent NPC disease in patients who had received at least one line of prior chemotherapy. Within this group, camrelizumab monotherapy achieved an objective response in 34% of patients (PFS 27% at 1-year; range across all three studies 20.5–34%). No NPC trial has yet reported on specific outcomes for non-PD1 checkpoint inhibitors but 11 on-going studies include alternative targets (e.g. PD-L1/CTLA-4) as combination or monotherapy treatments. In considering checkpoint immunotherapies for NPC, initial results show promise for anti-PD1 interventions. Further phase I–III trials are in progress to clarify clinical outcomes, fully determine safety profiles, and optimize drug combinations and administration schedules. 相似文献
5.
6.
7.
8.
For children with Developmental Coordination Disorder (DCD), the real-time coupling between frontal executive function and online motor control has not been explored despite reported deficits in each domain. The aim of the present study was to investigate how children with DCD enlist online control under task constraints that compel the need for inhibitory control. A total of 129 school children were sampled from mainstream primary schools. Forty-two children who met research criteria for DCD were compared with 87 typically developing controls on a modified double-jump reaching task. Children within each skill group were divided into three age bands: younger (6–7 years), mid-aged (8–9), and older (10–12). Online control was compared between groups as a function of trial type (non-jump, jump, anti-jump). Overall, results showed that while movement times were similar between skill groups under simple task constraints (non-jump), on perturbation (or jump) trials the DCD group were significantly slower than controls and corrected trajectories later. Critically, the DCD group was further disadvantaged by anti-jump trials where inhibitory control was required; however, this effect reduced with age. While coupling online control and executive systems is not well developed in younger and mid-aged children, there is evidence of age-appropriate coupling in older children. Longitudinal data are needed to clarify this intriguing finding. The theoretical and applied implications of these results are discussed. 相似文献
9.
《The journal of sexual medicine》2015,12(10):2004-2012
IntroductionResveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H2S) is a potent vasodilator and neuromodulator generated in corpus cavernosum.AimsWe investigated whether RVT caused the relaxation of mice corpus cavernosum (MCC) through H2S.MethodsH2S formation is measured by methylene blue assay and vascular reactivity experiments have been performed by DMT strip myograph in CD1 MCC strips.Main Outcome MeasuresEndothelial NO synthase (eNOS) inhibitor Nω-Nitro-L-arginine (L-NNA, 0.1 mM) or H2S inhibitor aminooxyacetic acid (AOAA, 2 mM) which inhibits both cystathionine-β-synthase (CBS) and cystathionine-gamma-lyase (CSE) enzyme or combination of AOAA with PAG (CSE inhibitor) has been used in the presence/absence of RVT (0.1 mM, 30 min) to elucidate the role of NO or H2S pathways on the effects of RVT in MCC. Concentration-dependent relaxations to RVT, L-cysteine, sodium hydrogen sulfide (NaHS) and acetylcholine (ACh) were studied.ResultsExposure of murine corpus cavernosum to RVT increased both basal and L-cysteine-stimulated H2S formation. Both of these effects were reversed by AOAA but not by L-NNA. RVT caused concentration-dependent relaxation of MCC and that RVT-induced relaxation was significantly inhibited by AOAA or AOAA + PAG but not by L-NNA. L-cysteine caused concentration-dependent relaxations, which are inhibited by AOAA or AOAA + PAG significantly. Incubation of MCC with RVT significantly increased L-cysteine-induced relaxation, and this effect was inhibited by AOAA + PAG. However, RVT did not alter the effect of exogenous H2S (NaHS) or ACh-induced relaxations.ConclusionsThese results demonstrate that RVT-induced relaxation is at least partly dependent on H2S formation and acts independent of eNOS pathway. In phosphodiesterase 5 inhibitor (PDE-5i) nonresponder population, combination therapy with RVT may reverse erectile dysfunction via stimulating endogenous H2S formation. Yetik-Anacak G, Dereli MV, Sevin G, Ozzayım O, Erac Y, and Ahmed A. Resveratrol stimulates hydrogen sulfide (H2S) formation to relax murine corpus cavernosum. 相似文献
10.